The novel centers around the experiences of a young girl named Haemimi, who becomes embroiled in the uprising and its aftermath. Through Haemimi's story, Han Kang skillfully conveys the ways in which trauma can be transmitted and reinscribed across generations, affecting individuals, families, and communities. The novel also explores the tensions between personal and national narratives, highlighting the ways in which official histories can erase or distort the experiences of marginalized groups.

The novel contrasts the state's attempt to reduce victims to "lumps of meat" with the survivors' efforts to preserve humanity through rituals like washing and shrouding the dead.

Human Acts is a novel that resists easy summary, but some of its key themes and motifs include: