Some menus require disabling your antivirus (false positives are common due to memory manipulation). Always scan files with VirusTotal before running.
As of this writing, three mod menus dominate the scene for Vice City Definitive Edition : gta vice city definitive edition mod menu
Most menus require an ASI loader or CLEO Redux to run custom scripts. Some menus require disabling your antivirus (false positives
This is the ultimate question. The original Vice City (2002) has thousands of mods, including total conversions like Vice Cry (graphics overhaul) and GTA: Vice City Stories PC port. However, the Definitive Edition has better controller support, native widescreen menus, and quality-of-life fixes (like checkpoint restarts). native widescreen menus
Modding can occasionally corrupt save files, so keep a clean copy of your progress before installing.