If you want a permanent copy, download (a massive Flash game preservation project). Inside, search for "Binding of Isaac." This is the safest method, though it requires admin rights to install.
In the pantheon of indie gaming, few titles have achieved the legendary status of The Binding of Isaac . Before Repentance , before Afterbirth+ , there was the raw, brutal, and beautifully twisted foundation: The Binding of Isaac with its first expansion, . i--- The Binding Of Isaac Wrath Of The Lamb Unblocked