You can create your own "GameShark 50" ISO using tools like PSX Cheat Converter and a blank CD-R, provided you own the original GameShark cartridge and dump its ROM.
: Version 5 is one of the few cheat discs that allows users to save and load custom cheat codes directly to a standard PS1 memory card. gameshark 50 psx iso
This is the most common use case. Emulators often have built-in cheat support, but the Gameshark ISO is preferred by purists who want the authentic menu experience or want to generate their own codes. You can create your own "GameShark 50" ISO